Commensal Flora, is it an Unwelcomed Companion as a Triggering Factor of Autoimmune Pancreatitis?

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Commensal Flora, is it an Unwelcomed Companion as a Triggering Factor of Autoimmune Pancreatitis?

The etiopathogenesis of many autoimmune disorders has not been identified. The aim of this paper is to focus on the involvement of bacterial exposure, as an environmental factor, in the pathogenesis of autoimmune pancreatitis (AIP), which is broadly categorized as autoimmune disorders involving pancreatic lesions. Avirulent and/or commensal bacteria, which may have an important role(s) as initi...

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Commensal flora and the regulation of inflammatory and autoimmune responses.

The gut microbiota has recently been recognized for its role in immune regulation, and changes in gut microbiota may be the basis for an increased incidence of autoimmune diseases and asthma in developed countries. Beneficial microbes produce factors that are distributed systemically, and therefore can influence peripheral inflammatory responses. Such symbiosis factors are important for the con...

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Autoimmune pancreatitis as a component of autoimmune polyglandular syndrome

Autoimmune pancreatitis (AIP) is a rarely diagnosed autoimmune illness with a characteristic clinical, histolog-ical, and radiological image [1]. The frequency of AIP occurrence is estimated to be 1.9–4%; however, this illness must be differentiated from the pancreatitis [2, 3]. The illness has two histological clinical sub-types: type 1: lymphoplasmacytic sclerosing pancreatitis (LPSP) – it ac...

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autoimmune pancreatitis: a case report

autoimmune pancreatitis is a fibro-inflammatory form of chronic pancreatitis. it is diagnosed by the combination of imaging studies such as a ct scan and pancreatography, laboratory analyses that include igg4 and/or autoantibodies, histopathological evaluations and positive response to corticosteroid therapy. we report the case of a 41-year-old female with a history of jaundice and increasing a...

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Autoimmune Pancreatitis: An Autoimmune or Immunoinflammatory Disease?

Autoimmune pancreatitis (AIP) has been widely presumed to be an autoimmune disease that is characterized by elevated IgG and/or IgG4, the presence of autoantibodies, and an infiltration of lymphocytes and plasma cells with fibrosis. However, no detailed immunological studies have been published. To define immunological changes in AIP in detail, and to review evidence for autoimmunity which may ...

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ژورنال

عنوان ژورنال: Frontiers in Physiology

سال: 2012

ISSN: 1664-042X

DOI: 10.3389/fphys.2012.00077